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薬理と治療
Abstract
Objectives Several clinical trials have reported that oral administration of Lactobacillus acidophilus L-92(L-92)alleviated allergic symptoms. We, therefore, evaluated the effect of oral ingestion of tablets containing L-92 on the symptoms of cedar pollen allergy. Methods We conducted a randomized, double-blind, placebo-controlled parallel-group study. Subjects were randomly divided into two groups, one group ingested two tablets containing 20.7 mg of L-92 and other group ingested placebo tablets for 12 weeks. During this period, subjects assessed their nasal and ocular symptoms every day. These symptoms were scored from 0(no symptom)to 4(very severe). The severity of the symptoms was evaluated based on the scores which subjects assessed by themselves. Blood samples were used to determine the concentration of non-specific IgE, anti-cedar IgE, and anti-cypress IgE. Results Itchy eyes score, ocular symptom score and ocular symptom-medication score of L-92 group were significantly lower compared with the placebo group. The score for sneezing tended to be improved compared with the placebo group. Anti-cypress IgE level in L-92 group was reduced compared with the placebo group in the 12-week period. Conclusion These results clearly suggest that oral administration of L-92 could alleviate the symptoms of pollen allergy. Trial registration UMIN-CTR:UMIN000030382
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