薬理と治療

Abstract

Objectives The objective of this study was to evaluate the safety of excessive intake of heat-induced yeast extract（Cerepron®）in healthy adult subjects. Methods An open trial was conducted in 10 volunteers（5 males and 5 females）. Volunteers were given 500 mg╱day of heat︱induced yeast extract for 4 consecutive weeks. Body weight, body mass index（BMI）, body fat percentage, blood pressure, heart rate, blood parameters, urine parameters, and subjective symptoms were recorded throughout the study. Results No adverse effects and no clinically concerning changes in body weight, BMI, body fat percentage, blood pressure, heart rate, blood parameters, urine parameters were observed throughout the study. Conclusions These results indicate that the excessive intake of heat-induced yeast extract （500 mg╱day for 4 weeks）was found to be safe in healthy adults.