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Lactobacillus paracasei MCC1849 を含有する栄養補助飲料の摂取による高齢者の免疫賦活効果―ランダム化非盲検並行群間比較試験―
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JPY
Abstract
Objective To investigate the effects of an oral nutritional supplement drink containing Lactobacillus paracasei MCC1849 on the immune system of elderly people. Methods A randomized open-label trial was conducted from March 2017 to October 2017 on 62 Japanese adult participants(aged≥65 years)who reported of daily fatigue. Participants were equally, but randomly, assigned to either the test or control beverage group(31 in each group) using a computerized random-number generator. They consumed one bottle of their assigned drink each day for 4 weeks. The effects on improving the immune system were assessed based on the immunological vigor scores, a questionnaire, salivary test, blood test, and physical examination at baseline and at 4 weeks. Results Sixty subjects were analyzed as per-protocol set(n=30 each). After consuming the drink, immune strength scores in the test beverage group were significantly higher than those in the control beverage group at 4 weeks(P<0.05). Furthermore, subjective symptoms such as“Ihave less laugh than before”(P<0.05)and“There is no definite reason, but I am tired”(P<0.05)were significantly alleviated. Conclusions Consumption of an oral nutritional supplement drink containing Lactobacillus paracasei MCC1849 for 4 weeks possibly improved the immune system of elderly people by preventing the decline of immune strength and improving quality of life-related subjective symptoms of fatigue. Trial registration UMIN-CTR: UMIN000026387 Foundation Clinico Co., Ltd.
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