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Toxicity Study of Single Oral Dose Administration of Acetic Acid Bacteria in Sprague—Dawley Rats
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JPY
Abstract
This study aimed at assessing the potential toxicity and the approximate lethal dose of the test substance, acetic acid bacteria(Gluconacetobacter hansenii), following a single oral administration in 6-week-old male and female Sprague-Dawley(Crl: CD(SD))rats. The test groups consisted of five animals(male and female)in each per group, namely, a dosing group administered with acetic acid bacteria at 2000 mg╱kg and a control group administered with water. All animals were monitored for clinical signs and changes in the body for a 14 day observation period after dosing, after which the animals were subjected to gross necropsy at the end of the observation period. No rats in the dosing group died during the observation period, and no effects on clinical signs, body weight, or necroscopic findings were observed in the dosing group. The approximate lethal dose of the test substance, acetic acid bacteria, was greater than 2000 mg╱kg in male and female rats under the conditions of this study.
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