薬理と治療

Abstract

Objectives We examined an intestine-conditioning activity of the dietary fiber-containing food. Methods We performed a double-blind, randomized, placebo-controlled, cross-over study to evaluate the effect of the test food which contained indigestible dextrin, Bacillus coagulans and fructooligosaccharide, on intestinal microflora and defecation frequency. The subjects were 45 healthy human volunteers, who tended to be constipation, and they were divided into three groups. On each of the 3 experimental periods, they took a placebo food or test food（low dose or high dose）for 2 weeks. Thirty nine subjects were eligible for analysis because 6 subjects were withdrawn from the study. Results The defecation frequency in both of low and high dose groups were increased significantly compared with those in placebo group. The occupancy rate of Bifidobacterium in feces in high dose group were higher than those in placebo group. No adverse events were observed, which were caused by the ingestion of the test food. Conclusion These results showed that the dietary fiber-containing food has intestinal-condition improving effect on healthy subjects（. UMIN Trial ID：UMIN 000031693）