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薬理と治療
Abstract
Objective The purpose of this randomized, placebo-controlled, double-blind, parallel-group study is to evaluate the influence of 12weeks ingestion of dietary supplement of low molecular fish collagen peptide to the knee joint pain and discomfort. Methods Fifty healthy adult male and female with the uncomfortable feeling of knee joint, were divided into active test and placebo groups. Subjects ingested active test dietary supplement(containing about 5 g fish collagen peptide)or placebo dietary supplement(not containing fish collagen peptide. maltodextrin powder)daily for 12 weeks. Knee joint pain and discomfort was assessed by changes in VAS survey and the questionnaire survey on knee joint function, at weeks 0, 4, 8, 12, and after 4 weeks from the end of 12 weeks ingestion. Results Each subject was determined the knee of the stronger pain (right or left)at the time of the screening and was followed the trend of that VAS value for 16 weeks. The VAS value of the low-molecular fish collagen group markedly decreased after initiation and the difference from the placebo group was significant after 4 weeks. The VAS value of the low-molecular fish collagen group decreased to 40.7% of the 0-week value at 12 weeks, whereas the decrease in the placebo group was 60.8%. Furthermore, even at 4 weeks after the end of ingestion, the VAS value of the low-molecular fish collagen group remained significantly lower value than at the start, and the value was equivalent to that at 12 weeks. On the other hand, in the placebo group, the 16-week VAS value increased to 76.1% of the 0-week value after the end of ingestion. The difference between this value and the 0-week value was not significant. The VAS value of another knee(non-target knee), and a questionnaire survey also showed the same results as above. No test food related adverse events were observed during the study, except one case(placebo group)of diarrhea due to overdose ingestion. Therefore, it was suggested that ingestion of this food for 12 weeks was safe and useful for improving knee joint pain and discomfort. Conclusion Dietary supplement containing low︱molecular fish collagen peptide improved knee joint pain and discomfort(. UMIN︱CTR ID:000029871)
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