Full text loading...
薬理と治療
Abstract
Objectives Foods containing aged garlic extract are thought to have an effect on fatigue during the rainy season and summer in Japan. The present study elucidated the suppressive effects of these foods on fatigue during winter and spring. Methods This randomized, double-blind, placebo-controlled parallel study included 52 healthy adult volunteers(male, n=19; female, n=33)who consumed a placebo or test food for eight weeks. Subjective mood(fatigue)was evaluated using the visual analogue scale and volunteers completed the stress arousal checklist and a questionnaire about cold sensation. Body temperature and salivary α︱amylase activities were also measured. The safety of this food was also evaluated by physical examinations and blood tests. Results The scores for fatigue and stress were significantly decreased after eight weeks of test food intake compared with the placebo. Salivary α-amylase activities in the test food group were significantly lower than those in the placebo group after eight weeks of intake. Sensitivity to cold improved and body temperature increased. There were no problems with safety. Conclusions Foods containing aged garlic extract can decrease fatigue and stress during winter and spring. The present results suggest that the mechanisms of action are the suppression of sympathetic nerve activity and improvement of blood circulation. Trial Registration UMIN-CTR: UMIN000024713
Data & Media loading...