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コラーゲンペプチド摂取による骨代謝マーカーへ及ぼす効果―ランダム化二重盲検プラセボ対照並行群間比較試験―
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JPY
Abstract
Objective The aim of this study was to investigate the effect of a dietary supplement containing porcine skin collagen peptides on bone metabolism on healthy subjects. Methods A randomized, double-blind, placebo-controlled parallel-group, comparison study was conducted in 24 healthy subjects(50-72 years old). The subjects were randomized into two groups and given either the test product(125 mL drink containing 10 g collagen peptides derived from porcine skin)per day or the control product(placebo drink)for 12 weeks. Serum and urinary biomarkers were evaluated for bone metabolism. Results The urinary biomarkers of bone metabolism were not significantly changed. However, the serum biomarker of bone metabolism(bone specific alkaline phosphatase(BAP))was significantly improved at 12 weeks in the test product group who took collagen peptides compared to the placebo group. Conclusions The results suggested that daily supplementation of collagen peptides derived from porcine skin might provide a beneficial effect on bone formation(. UMIN-CTR000033460)
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