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熟成にんにくエキス含有食品摂取による疲労感および睡眠の質に関する研究―ランダム化二重盲検プラセボ対照並行群間比較試験―
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JPY
Abstract
Objectives This study investigated the effects of foods containing aged garlic extract on fatigue and quality of sleep. Methods This randomized, double-blind, placebo-controlled parallel study included 29 healthy volunteers (12 males, 17 females)who consumed a placebo or test food for twelve weeks. Subjective mood (fatigue, quality of sleep)was evaluated using the visual analogue scale(VAS), and the OSA sleep inventory MA version(OSA-MA)was administered. Serum superoxide dismutase and glutathione peroxidase(GPx)levels and urinary isoprostane levels were measured. Results Significant differences between the test and placebo groups were observed for the VAS scores for fatigue and quality of sleep. The VAS score for fatigue was significantly decreased after twelve weeks of test food intake. The VAS score of quality of sleep was significantly elevated after twelve weeks of test food intake. The total OSA-MA score, the score for sleepiness at rising, sleep onset-sleep maintenance, and fatigue recovery were elevated. Serum GPx levels in the test food group were significantly higher than those in the placebo group after twelve weeks. Urinary isoprostane levels in the test food group were significantly lower than those in the placebo group after twelve weeks. Conclusions Foods containing aged garlic extract can decrease fatigue and improve quality of sleep. There is the possibility that the mechanism of action is improved antioxidant activity in the body. Trial registration UMIN-CTR: UMIN000029107
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