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Lactobacillus curvatus CP2998 株継続摂取による健常高齢者の運動機能改善効果―無作為化二重盲検プラセボ対照並行群間比較試験―
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JPY
Abstract
Objectives The aim of this study was to evaluate the effects of administration of Lactobacillus curvatus CP2998 on physical function, body composition and health-related quality of life (HR-QOL)in the older adults. Methods We performed a randomized, double-blind, placebo-controlled, parallel-group trial. A total of 130 subjects aged from 65 to 79 without excessive exercise habits were randomly divided into two groups and were administered CP2998(5*10 11 cells╱day)(n=65)or placebo (n=65)once a day for 12 weeks. Physical function, body composition and HR︱QOL(SF-36) were assessed at 0, 6, and 12 weeks. Results In the CP2998 group, gait speed, cadence, surface electro-myography, SF-36(mental health and vitality)were increased significantly at 12 weeks compared with those in the placebo group(P<0.05). No significant changes in body composition were observed with CP2998 intake. Conclusions The present study shows that the 12 weeks of continuous ingestion of CP2998 is effective in improving the gait function and mental health of the older adults.
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