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薬理と治療
Abstract
Objectives A randomized, double-blind, placebo-controlled, cross-over study was conducted to confirm the effect of food containing Terminalia bellirica extract on postprandial elevation of blood glucose levels. Methods Fifty volunteer subjects with either high-normal plasma glucose levels after fasting, or with borderline diabetes were selected. These subjects had fasting blood glucose levels between 100 and 125 mg╱dL, or 2-hour glucose values between 140 and 199 mg╱dL in the 75g oral glucose tolerance test, and causal blood glucose levels under 200 mg╱dL. The subjects were randomly divided into two groups. The experimental group ingested food containing T. bellirica extract(containing 20.8 mg gallic acid), while the control group ingested unmodified food as a placebo, before both groups ingested the loading diet. Blood glucose levels were measured before ingestion, and 30, 60, 90, and 120 min after ingestion. Results Consumption of the food with T. bellirica extract significantly suppressed the postprandial elevation blood glucose levels compared to the food consumed by the placebo group. The incremental area under the curve representing change in blood glucose levels from 0 min was smaller in the experimantal group than in the placebo group(P<0.05). Also, the changes in blood glucose levels from 0 to 30 min after loading were significantly lower in the experimental group than in the placebo group(P<0.05). During this study period, no adverse events were observed that could be attributed to the food containing T. bellirica extract. Conclusions These results indicate that ingestion of food containing T. bellirica extract can inhibit postprandial elevation of blood glucose levels.( UMINCTR ID: UMIN000035710)
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