Full text loading...
薬理と治療
Abstract
Objective Vine tea extract made from the leaves of Ampelopsis grossedentata is known to perform multiple pharmacological rules. The purpose of the present study was to evaluate the safety of an excessive intake of the vine tea extract in healthy adults. Methods A randomized, double-blind, placebo-controlled, parallel-group comparison study was conducted on 100 healthy adults aged between 20 and 64 years of age(both female and male). Subjects consumed either dietary supplement containing 2500 mg of vine tea extract that contained 750 mg of ampelopsin or placebo for four consecutive weeks. Safety of an excessive intake of the vine tea extract was evaluated by the physical measurements, blood tests, urinalysis and adverse events. Results The results showed several significant differences in physical measures and blood tests between the two groups, but these differences were considered to be unrelated to the intake of the vine tea extract nor placebos. In addition, there was one case of constipation in the vine tea extract group, which may not deny the relation to the intake of the supplement. However, it was judged as a mild adverse event by the investigator, and was considered as a gastrointestinal symptom. Conclusions No safety problem was observed in an excessive intake of the vine tea extract under the present evaluation condition. (UMIN ID: UMIN000033201)
Data & Media loading...