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Effects of Intake of Psyllium Husk on Blood Pressure in Subjects with High—normal Blood Pressure―Randomized, Double—blind, Placebo—controlled Parallel—group Study―
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JPY
Abstract
Objectives This study aimed to investigate the effects of psyllium husk intake on blood pressure in high-normal blood pressure subjects. Methods A randomized, double-blind, placebo-controlled, parallel-group study was conducted in 72 high-normal blood pressure subjects. The subjects were randomly assigned to either the psyllium group(n=36)or the placebo-controlled group(n=36). The subjects consumed the study product before each of the three daily meals for 12 weeks. The psyllium group consumed test food containing 3.6 g of dietary fiber derived from psyllium husk at a time, and the placebo group consumed control food without dietary fiber derived from psyllium husk. The changes in the blood pressure levels of the two groups were compared. Results Seventy subjects completed the study. Systolic blood pressure(SBP)and diastolic blood pressure(DBP)of the two groups were not significantly different. However, subgroup analysis of subjects whose estimated daily salt intake during the study were above the mean of subjects revealed that the change from baseline to Week 12 in SBP was significantly greater in psyllium group(P<0.05). Conclusion These results suggest that continuous intake of dietary fiber derived from psyllium husk decreases SBP in high-normal blood pressure subjects with a high salt intake. (UMIN000035223)
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