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薬理と治療
Abstract
Objectives We evaluated the effects and safety of green tea containing mono-glucosylrutin on visceral fat in this randomized, double-blind, placebo-controlled, parallel-group comparative study. Methods Two hundred healthy Japanese people with a body mass index≥23 and<30 were randomly divided into test and placebo groups. Subjects drank the test green tea(containing 65 mg mono-glucosylrutin)or placebo green tea(not containing mono-glucosylrutin)daily for 12 weeks. Physical, blood, and urinary examinations and medical interviews were conducted at weeks 0, 4, 8, and 12, and at 4 weeks after the end of the trial period. Measurement of visceral fat was performed at weeks 0, 8, and 12, and at 4 weeks after the end of the trial period. Results There were no differences in visceral fat between the two groups. However, in younger subjects, the volume of visceral fat was significantly smaller in the test green tea group compared with the placebo green tea group at week 12. No abnormal changes or severe adverse events were observed with physical, blood, and urinary examinations nor reported during medical interviews during the trial. Conclusions Green tea containing mono-glucosylrutin was safe over the long term and might decrease visceral fat in people of a particular age. The biological mechanisms for these results require study(. UMIN000020824)
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