薬理と治療

Abstract

Objective　Tomato- or citrus-derived dietary fiber has been suggested to attenuate postprandial blood glucose elevation. Here, we investigated the effects of these dietary fibers on postprandial blood glucose in healthy subjects. Methods　Two placebo-controlled, crossover studies were conducted. In the study 1, water （W）, placebo（P1）, tomato fiber-fortified beverage（T1）, citrus fiber-fortified beverage （C1） were used at least intervals of 3 days between the tests. Fourteen subjects consumed either of 4 beverages at immediately before eating 150 g of cooked rice, and blood glucose levels were measured 8 times in 180 min. In the study 2, placebo （P2）, tomato fiber-fortified beverage （T2）, citrus fiber-fortified beverage（C2）were used. The study was conducted in 33 subjects in the same method with the study 1. In each study, blood glucose levels, maximum concentration of Δblood glucose levels（ΔCmax）, incremental area under the curve calculated for 60 min or 180 min （IAUC60 min and IAUC180 min, respectively）were compared between placebo group and the other groups. Results　In the study 1, T1 and C1 significantly suppressed blood glucose levels at 60 min compared with P1. There were no significant differences among groups for ΔCmax and IAUC. In the study 2, T2 and C2 suppressed blood glucose levels at 15 min and at 30 min, ΔCmax, IAUC60 min compared with P2. Conclusions　These results suggest that tomato- or citrus-derived dietary fiber attenuate postprandial blood glucose elevation, especially suppress or delay absorption of glucose in a short time after a meal（. UMIN ID: UMIN000034771, UMIN000036045）