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Phycocyanin Reduces Transepidermal Water Loss and Improves Skin Barrier Functionin Healthy Subjects―A Randomized, Double—blind, Placebo—controlled, Parallel—group Comparison Trial―
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JPY
Abstract
Objective Phycocyanin, a biliprotein, possesses antioxidant and anti-inflammatory properties, and, thus, is a promising food substance with various functions for health promotion. The present study investigated the effects of phycocyanin derived from Spirulina on skin function in healthy subjects in a randomized, double-blind, placebo-controlled trial. Methods Ninety-six subjects were randomly assigned to the test food 410 mg of phycocyanin (C-phycocyanin 300 mg, allophycocyanin 110 mg)and placebo groups. The test food and placebo were administered to the respective groups for 8 weeks. Transepidermal water loss (TEWL)was the primary outcome, and the visual analogue scale(VAS)was the other outcome. Results Among subjects with a TEWL level between 10 g╱m2╱hr and higher to less than 20 g╱m2╱hr(normal value in healthy human)at 0 weeks, TEWL levels at 8 weeks were significantly lower in the test food group than in the placebo group. In the VAS, scores for skin elasticity and skin gloss at 4 and 8 weeks and those for skin moisture at 8 weeks were significantly higher in the test food group than in the placebo group. Conclusion The administration of 410 mg of phycocyanin(C-phycocyanin 300 mg, allophycocyanin 110 mg)for 8 weeks reduced TEWL and improved skin barrier function in healthy subjects. Furthermore, the effects of phycocyanin on skin function were also detected physically in the VAS. (UMIN ID: 000035205)
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