薬理と治療

Abstract

Objective　The aim of this study was to evaluate the effects of eating food containing paramylon derived from Euglena gracilis EOD-1, in terms of feelings of fatigue in daily life. Methods　A randomized, double-blind, placebo-controlled, parallel-group comparison study was conducted in healthy adults（n＝197）. The subjects ingested either a placebo or a test food containing 350 mg paramylon derived from Euglena gracilis EOD-1 daily for 4 weeks. Subjects ʼ reported feelings of fatigue were evaluated using the Visual Analog Scale. Results　Subjects reported significantly less feeling of physical fatigue after 4 weeks of consuming the test food than after 4 weeks of consuming the placebo food. In addition, the time spent outdoors and the increment of number of walks were significantly higher after the ingestion of the test food than after the ingestion of placebo food. Conclusions　These results indicated that ingesting paramylon derived from Euglena gracilis EOD-1 at 350 mg per day in a test food item for 4 weeks reduces feelings of physical fatigue. In addition, prolonged time spent outdoors and increased change rate of number of walks were confirmed, which may be derived from a reduction in the feelings of physical fatigue. （UMIN-CTR ID：UMIN 000036296）