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薬理と治療
Abstract
Objective Whey peptide-containing drink(WPD)is expected to be effective for rehydration in human because whey peptide reportedly promotes water absorption in rat intestine. In this study, we aimed to test the effectiveness of WPD for exercise-induced mild dehydration in healthy men. Methods WPD containing 0.3% whey peptides, 17 mM Na, and 0.8% carbohydrates was used as a test solution. Nineteen healthy men were instructed to exercise on treadmills and bicycle ergometers for 1 hour and then to ingest either WPD or mineral water(MW). Blood sampling, physical examinations, and examinations of subjective symptoms were done before and immediately after exercise, and then at 30 and 60 min after ingestion. Changes in plasma volume were calculated and used as primary outcomes.Results Plasma volume change at 30 min after ingestion of WPD was significantly higher than that after ingestion of MW(P<0.05). Furthermore, feelings of fatigue, pain in foot muscles, and a sense of abdominal distension were reduced after ingestion of WPD. Conclusions These results suggested that WPD was absorbed more quickly than MW and an effective treatment for exercise-induced mild dehydration.
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