薬理と治療

Abstract

Objectives　To evaluate the effects of a multi plant-herbal dietary supplement containing 40 mg of Gymnema sylvestre extrac（t containing gymnemic acid）, 200 mg of mulberry leaf extract, 200 mg of green tea extract, 100 mg of chitosan, 4.8 mg of kidney bean extract, and 150 mg of Kaempferia parviflora extract on body fat and body weight. Methods　A prospective, randomized, double-blind, placebo-controlled, and parallel group comparison study was performed from March 2016 to December 2016 in the National Institute of Nutrition in Vietnam. Six hundred seventy-three participants aged 45-64 years were screened by their body mass index（BMI）. The participants were randomized either a multi plant-herbal dietary supplement or placebo tablets, for 12 consecutive weeks. The primary outcome measures were abdominal fat areas, and the secondary outcome measures were body weight, BMI, and body fat percentage. The abdominal fat was assessed by computed tomography method. Results　Of 673 participants screened, 112 with their BMI were between 23 and 30（overweight or classⅠ obese）were enrolled in this study. Of these, 46 in the placebo and 44 supplement group subjects completed the study. For the abdominal fat area, significant reduction effects of the dietary supplement were observed in both visceral and total abdominal fat area（P＜0.01）. Body weight, BMI, and body fat percentage were also decreased by the supplement intake compared with those of placebo. Conclusions　Intake of this dietary supplement containing Gymnema sylvestre extract（containing gymnemic acid）, mulberry leaf extract, green tea extract, chitosan, kidney bean extract, and Kaempferia parviflora extract reduced both visceral and total abdominal fat and body weight. This supplement will be a new option for improvement of overweight and the prevention of obesity-related disease（. Clinical Trial Registration: UMIN000029053）