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薬理と治療
Abstract
Objectives The objective of this study was to analyze the effect of intake of pure sesame oil containing sesamin and sesamolin on serum low density lipoprotein(LDL)cholesterol levels in subjects with borderline and mildly high LDL level using stratified analysis. Methods We conducted a randomized, double-blind, parallel-group, placebo-controlled study, using Kadoya Pure Sesame Oil as the test food. Japanese adults with LDL cholesterol levels of 120-159 mg/dL were enrolled and randomly assigned to 3 groups: placebo, low-dose (10 g of test food daily), and high-dose(14 g of test food daily)(36 subjects for each group). The period of intake was 12 weeks. Levels of serum LDL cholesterol were determined at the baseline and 4, 8, and 12 weeks from the onset of the intake period. The effect of test food intake was analyzed after stratification by LDL cholesterol level at baseline: healthy subjects with borderline LDL levels(120-139 mg╱dL)or subjects with mildly high LDL levels(140-159 mg╱dL). Results In subjects with borderline LDL levels, daily intake of 10 g test food significantly lowered serum LDL levels, but intake of 14 g test food did not have significant effect on serum LDL. On the other hand, in subjects with mildly high LDL levels, serum LDL levels were significantly lowered in high-dose group, but not in low-dose group. Conclusions In healthy adults with borderline serum LDL cholesterol levels, continuous intake of 10 g Kadoya Pure Sesame Oil may improve LDL cholesterol control.
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