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酢酸菌(Gluconacetobacter hansenii GK—1)はスギ花粉による鼻の不快感を軽減する―ランダム化二重盲検プラセボ対照並行群間比較試験―
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JPY
Abstract
Objectives We aimed to determine whether the ingestion of acetic acid bacteria could reduce the symptoms of Japanese cedar-pollen allergy. Methods We conducted a randomized double-blind placebo-controlled study. 84 Japanese males and females(mean age: 38.6±10.1 years)with allergic rhinitis triggered by Japanese cedar pollen were randomly assigned to an acetic acid bacteria group or a control group. The subjects ingested acetic acid bacteria(30 mg/day)or placebo for 8 weeks. Nasal discomfort was evaluated using the Japanese Rhinoconjunctivitis Quality of Life Questionnaire at preingestion and at 4 and 8 weeks during the ingestion period. Results The acetic acid bacteria group had a significantly lower nasal discomfort score compared to the control group at 4 weeks after ingestion(P <0.05)with no adverse effects observed. Eye discomfort were not affected by acetic acid bacteria. Conclusion Our findings suggest that the continuous ingestion z of acetic acid bacteria relieves nasal discomfort of Japanese cedar pollinosis. (JMA-IIA00432)
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