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Effects of Intake of Collagen Peptides on Flow—mediated Dilation(FMD)in Healthy Volunteers with Relatively Low FMD Levels―A Randomized, Double—blind, Placebo—controlled, Parallel—group Study―
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JPY
Abstract
Background The collagen octapeptide Gly-Ala-Hyp-Gly-Leu-Hyp-Gly-Pro inhibits angiotensin converting enzyme and its positive effects on blood pressure and vascular function are suggested. Objective To verify safety and the effect of the collagen octapeptide Gly-Ala-Hyp-Gly-Leu-Hyp-Gly-Pro on vascular endothelial function(flow-mediated dilation; FMD)in a randomized, double-blind, placebo-controlled, parallel-group study. Methods/study design Volunteers(n=50), aged 20-64 years, whose FMD level was relatively low were randomly assigned to an investigational food that contained 3.9 mg of the collagen octapeptide Gly-Ala-Hyp-Gly-Leu-Hyp-Gly-Pro(group A)or a placebo food(group P)(1:1). FMD was assessed in pre-trial period and during the investigational food intake period of 8 weeks, and changes in values between the pre-trial and the last of the observationperiod(ΔFMD)were compared between groups. Results Although the endpoint measures were not significantly different between the two groups in per protocol set (n=22 and 23 in groups A and P, respectively), stratified analyses revealed significant differences in ΔFMD at week 8. In subjects with their habitual alcohol intake frequency at ≤0.5 times/week(group A, n=11; group P, n=12)or habitual alcohol consumption at ≤13.5 g/week(group A, n=10; group P, n=13), ΔFMD values in group A were significantly higher than those in group P(+1.68±1.16% vs. -1.28±0.49%, P=0.024;and+2.09±1.11% vs. -1.23±0.45%, P=0.006). No serious adverse event related to the active food intake was observed. Conclusion Benefit of the collagen octapeptide Gly-Ala-Hyp-Gly-Leu-Hyp-Gly-Pro intake on vascular endothelial function is suggested. (UMIN study ID:UMIN000031071)
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