No data available.
Please log in to see this content.
You have no subscription access to this content.
The full text of this article is not currently available.
Safety Evaluation of Excessive Rose Hip Extract Intake in Healthy Subjects―A Randomized, Placebo‒controlled, Double‒blind, Parallel‒group Study―
Rent:
Rent this article for
JPY
Abstract
Objective The aim of this study was to evaluate the safety of five times more than regular daily intake of rose hip extract for four weeks. Method This randomized, placebo-controlled, double-blind, parallel-group study included a total of 81 individuals who provided informed consent; 44 subjects who met the inclusion criteria were allocated equally but randomly into either the intervention or the placebo group(n=22/group), using a computerized random-number generator. The subjects were asked to chew five tablets of either 100-mg rose hip extract(five times more than the regular daily intake)or placebo after breakfast every day for four weeks. The studies were conducted from September 2018 to December 2018, and the safety evaluation included physical examination, urinalysis, blood analysis, and subjective symptoms. Results The final analysis included data from 22 subjects each in the intervention and placebo groups. Medical-related problems were not observed in the safety evaluation. In addition, no adverse effects from the test food were reported. Conclusion Under the conditions of this study on healthy Japanese subjects, excessive intake of rose hip extract for four weeks was found to be safe. UMIN-CTR:UMIN000034151 Funder:Morishita Jintan Co., Ltd.
Full text loading...
/content/article/0386-3603/48020/203