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ひざ関節に違和感がある健常者を対象としたラブダン型ジテルペン類化合物含有食品の摂取によるひざ関節の違和感に対する影響
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JPY
Abstract
Background The knee joint problem is one of the major problems for elder people. Labdane, which is contained in white turmeric leaf, has demonstrated to inhibit degradation of hyaluronic acid(HA). Since HA is important for lubricating joints, Labdane is expected to have a role to maintain good joint health. Objectives This study aimed at validating the effects of Labdane on discomfort in the knee joint. Methods In a single-arm open-label trial, 33 healthy subjects(ages 44 to 93 years) with a discomfort in the knee joint received 6.4 mg of the Labdane per day for 12 weeks. The discomfort of the knee joint was measured every 4 weeks from the start of intake until 12 weeks after beginning the test food ingestion using visual analogue scale(VAS). Results The results of each VAS score were 5.2±2.6 at 0 weeks, 3.8 ±3.0 at 4 weeks, 2.7± 2.5 at 8 weeks and 2.5±2.9 at 12 weeks. Significant differences were observed at 4 weeks (P=0.002), 8 weeks(P<0.001)and 12 weeks (P<0.001)against the 0 weeks of intake. Conclusions This study concluded that taking the Labdane 6.4 mg/day for 4, 8, 12 weeks in healthy adult men and women with a discomfort in the knee joint is significantly effective.
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