Full text loading...
薬理と治療
Abstract
Objectives To evaluate the effects of Geranium dielsianum extract administration on orchiectomized mouse male accessory sex glands, in order to determine the presence or absence of androgenic effect on male. Methods ddY male mouse with sham operation group and orchiectomized mouse group (ORX group)were prepared. After 14 days of oral administration(ORX+GD group)of Geranium dielsiaum, the prostate gland size was horizontally and vertically measured along with the weight of seminal vesicle and prostate gland. Results The size of the prostate gland in ORX group and ORX+GD group was significantly smaller than the sham operation group due to orchiectomy, however between ORX group and ORX+GD group no significant difference was observed. Seminal vesicle(including prostate gland)wet weight in ORX group and ORX+GD group showed significantly diminution compared with the sham ope group, however between ORX and ORX+GD group there was not a significant difference. Conclusion GD extract did not affect accessory gonad including seminal vesicle and prostate of male orchiectomized mouse, therefore GD does not have androgenic effect.
Data & Media loading...