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Lactobacillus acidophilus L—55 含有発酵乳による通年性アレルギー性鼻炎症状の緩和効果―ランダム化プラセボ対照二重盲検並行群間比較試験―
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JPY
Abstract
Objectives The aim of this study was to evaluate whether the intake of fermented milk with Lactobacillus acidophilus L-55(L-55)alleviated subjective symptoms of perennial allergic rhinitis. Methods We performed a randomized, double-bind, placebo-controlled, parallel-group comparison study. Fifty Japanese subjects were randomly divided into two groups and ingested fermented milk with L-55(2.0×109 cells)or placebo once a day for 12 weeks. Allergic subjective symptoms were evaluated using the Japanese Rhino-conjunctivities Quality of Life Questionnaire once every two weeks at preingestion and during the ingestion period. Additionally, to assess the safety of this study beverage, a physical and blood examination were performed. Results Itchy nose score and itchy eyes score of L-55 group were significantly lower compared with the placebo group at 8 weeks and 4 weeks after ingestion, respectively. Furthermore, the L-55 group had a significantly lower the quality of life(QOL)score about social life compared to the placebo group at 6 weeks after ingestion. There were no adverse effects due to the ingestion of the beverage. Conclusion These results suggest that daily intake of L-55 can improve nasal and ocular symptoms in the subjects of perennial allergic rhinitis. (UMIN000035776)
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