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Intake of 200 mg/day of γ—Aminobutyric Acid(GABA)Improves a Wide Range of Cognitive Functions ―A Randomized, Double—blind, Placebo—controlled Parallel—group Clinical Trial―
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JPY
Abstract
Background/Objectives Cognitive function, which refers to intellectual abilities such as memory, attention, language, and judgment, declines with age. As the aging population of the world increases, it is important to prevent cognitive decline in the elderly before they develop dementia. The objective of this study was to evaluate the effect of intake 200 mg of γ-aminobutyric acid(GABA)on cognitive function in healthy adult subjects aged over 40 years. Methods This was a randomized, double-blind, placebo-controlled, parallel-group clinical trial. Thirty healthy participants were each assigned to either the placebo group or the GABA group; those in the latter group were given capsules containing 200 mg GABA daily for 12 weeks. Cognitive functions were assessed using Cognitrax and the Repeatable Battery for the Assessment of Neuropsychological Status(RBANS)test. Quality of life(QOL)was assessed using the MOS 36-Item Short-Form Health Survey(SF-36). Results GABA improved or maintained cognitive function on the domain of Non-Verbal Reasoning, Working Memory, and Sustained Attention in Cognitrax and on the domain of Visuospatial/Constructional and Delayed Memory in RBANS. Regarding QOL, the GABA group showed significant improvement in SF-36 domain of Role-Physical, Vitality, and Mental Health. IGF-1 levels within the GABA group increased in comparison to the levels before intake. No adverse effects or clinically concerning changes were observed. Conclusions These results indicate that GABA treatment appeared to safely enhance a wide range of cognitive functions in healthy adults. (UMIN000036725)
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