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ピセアタンノールおよびコラーゲンペプチド,エラスチンペプチド,ヒアルロン酸4 糖との組合わせが線維芽細胞でのヒアルロン酸合成へ与える影響
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JPY
Abstract
Objective The aim of this study was to investigate whether piceatannol(PIC) induces hyaluronan synthesis in cultured fibroblasts. In addition, the effect of treatment with combination of PIC, collagen-derived dipeptide prolyl-hydroxyproline(Pro-Hyp), elastin-derived dipeptide prolyl-glycine(Pro-Gly)and hyaluronan tetrasaccharide(HA4)on hyaluronan synthesis in cultured fibroblasts was evaluated. Methods The mRNA expression level of hyaluronan synthase 1(HAS1)and hyaluronan synthase 3(HAS3)in cultured fibroblasts after treatment with PIC were evaluated by quantitative real-time PCR. The mRNA expression level of HAS1 in cultured fibroblasts after treatment with combination of PIC, Pro-Hyp, Pro-Gly and HA4 was also investigated. Results The mRNA expression of HAS1 and HAS3 were upregulated by PIC in cultured fibroblasts. In addition, treatment with combination of PIC, Pro-Hyp, Pro-Gly and HA4 upregulated HAS1 mRNA expression. Conclusions These results suggest that PIC, Pro-Hyp, Pro-Gly and HA4 might affect skin moisture by inducing hyaluronan synthesis in dermal fibroblasts.
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