薬理と治療

Abstract

Introduction　This study examined effects of Longvida® Optimized Curcumin®, with various probable physiological activity effects, on alcohol metabolism. Methods　A randomized, double-blind, placebo-controlled, parallel-group crossover study was conducted in healthy Japanese males. The alcohol patch test was used to select a total of 15 subjects who did not exhibit extremely low alcohol tolerance. Subjects were divided into two groups: test food group（containing Longvida®）and placebo food group. The primary and secondary outcomes were assessed before and up to 180 min after alcohol loading. The primary outcomes were measured with blood alcohol and acetaldehyde levels and breath alcohol levels. The secondary outcomes were determined by a questionnaire survey. Results　One subject withdrew consent during the study; thus, 14 subjects were included in the final analysis. No significant differences were found between the groups regarding blood or breath alcohol levels. Blood acetaldehyde level in the test food group 180 min after alcohol loading was significantly lower than that in the placebo food group. Conclusion　The results of this study suggest that Longvida® Optimized Curcumin® enhances the metabolism of blood acetaldehyde after alcohol consumption. Traial Registration Japan Primary Registries Network　UMIN000014995