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薬理と治療
Abstract
Objective Low back discomfort is one of the factors affecting quality of life(QOL)in Japan. The aim of this study was to investigate the ability of a compound supplement containing astaxanthin and long pepper to improve the low back discomfort. Methods We conducted a randomized double-blind, placebo-controlled, parallel-group study using 79 healthy participants with low back discomfort in daily life aged 21 to 59. They were administered with a supplements containing astaxanthin(6 mg/day)and long pepper extract powder(90μg as piperins╱day)or a placebo food for 8 weeks. The primary outcome was measured by the scores of Japan Low Back Pain Evaluation Questionnaire(JLEQ)and Lumbar range of motion. The secondary outcome was measured by Trunk muscle strength, core temperature, and Visual Analogue Scale(VAS)questionnaire. Results The result with all subjects, the primary outcome(JLEQ and Lumbar range of motion)was not significantly improved in supplement group compared with the placebo at 8 weeks. Although, the changes in VAS questionnaire from baseline for 8week in half rising and lean forward postures(such as face washing)was significantly improved in supplement group compared with the placebo group. (placebo group: -13.1±12.9 mm, supplement group: -24.5±18.0 mm). Next, the subjects“, the degree of low back discomfort was greatly changed during the time before administering”excluded, were analyzed. In this result, JLEQ was significantly improved in supplement group compared with the placebo group at 8 weeks. (placebo group: -12.9±11.2 mm, supplement group: -19.5±11.0 mm)Moreover, the changes in VAS questionnaire from baseline for 8week in half rising and lean forward postures(such as face washing)was significantly improved in supplement group compared with the placebo group. No serious adverse events were observed. Conclusions Administration of astaxanthin and long pepper improves the low back discomfort. Notably, the improvement effect was prominently visible in half rising and lean forward postures(such as face washing). UMIN ID UMIN000036216
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