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薬理と治療
Abstract
Background In recent years, the prevalence of neurological diseases such as dementia and depression have become a social problem. If functional food ingredients have an improving effect on a state in which cognitive function is little reduced and depressive condition is very mild, that will be significant from the viewpoint of prevention of onset. Method From 1659 healthy subjects aged over 18 years, using Chinese-medical questionnaire, we screened subjects who were under the Qi deficiency and/or Qi depressive constitutions, and 46 cases who agreed to the test were targeted. We evaluated changes in brain activation status due to language fluency task using functional Near-Infrared Spectroscopy(fNIRS) before and 1 hour after single ingestion of drinks containing ginkgo biloba extract, curcumin, L-carnitine, long pepper extract and trans glycosylated hesperidin. Changes in scores of Chinese-medical constitution and subjective symptoms were also evaluated. Results Integral value of oxygenated hemoglobin in the frontal lobe measured by fNIRS 1 hour after single drink intake was significantly reduced compared to before intake. In the Chinese-medical constitution score, Yang deficiency(warmness dysfunction), Yin deficiency(lack of body fluid), Phlegm wetness(edema tendency), Wet heat(edema+heatization), Blood stasis(peripheral circulation disorder)constitution scores before drink intake was significantly improved after intake. For subjective symptoms, physical fatigue and mental symptoms were significantly improved. No adverse events due to drink intake were observed. Conclusion The decrease in oxygenated hemoglobin integral value by the single drink intake means that oxygen consumption decreased in the task execution. Furthermore, the performance for language fluency task was significantly improved. Therefore, the findings suggest that the drink is believed to have an effective brain activation effect. (UMIN-ID: UMIN000031904)
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