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薬理と治療
Abstract
Objective We investigated whether intake of Lactobacillus brevis KB290(KB290)could increase skin hydration in healthy females with dry skin. Methods Two randomized, double-blind, placebo-controlled studies were conducted. In the study 1, 70 of relatively young subjects ingested a bottle of the active drink(containing more than 3.5 billion of KB290)or the placebo drink for 4 weeks. Skin conditions including levels of water content in stratum corneum and transepidermal water loss, levels of fecal putrefactive metabolites, and fecal microbiota were evaluated before and after intake. In the study 2, 97 subjects with wide range of age consumed the active drink(containing more than 1.4 billion of KB290)or the placebo drink, and were evaluated the skin conditions before and at the 4 and 8 week of the intervention period. Results In the study 1, 64 subjects were analyzed and the changes of water content in stratum corneum of the forearm and neck were significantly higher in the group consumed the active drink(KB290 group)than the group consumed the placebo drink(placebo group). In addition, change of fecal microbiota composition significantly differed between the two groups. In the study 2, 94 subjects were analyzed and the changes of water content on the forearm and cheek in the KB290 group were significantly higher than the placebo group at the 4 and 8 week of the intervention period. Conclusions These results suggested that intake of KB290 increased skin hydration in healthy females with dry skin, probably via modulation of intestinal microbiota. (UMIN-CTR ID:000034215, 000038300)
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