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薬理と治療
- Authors: Hiroshi Ashigai1, et al.
Abstract
Background Eyestrain is a serious quality of life problem, especially in the workplace. In particular, work at visual display terminals(VDTs)is a common cause of eyestrain. Monoglucosyl rutin(MGR)is a highly water-soluble α-glucose adduct of rutin. Previous studies have demonstrated that rutin improved dry eye. This randomized, placebo-controlled, double-blind, crossover study was aimed at evaluating the efficacy of oral mono-glucosyl rutin against eyestrain caused by exposure to a visual display terminal(VDT). Method This study was designed as a randomized, placebo-controlled, double-blind, crossover study. The participants included thirty healthy Japanese men and women who tended to feel eyestrain. During the first test period, the participants were asked to drink either a test food containing 254 mg of MGR or a placebo food without MGR. After the food intake, the participants did personal computer work at VDT for 30 min and then relaxed for 20 min. We evaluated the participantsʼ eyestrain using an objective parameter (high -frequency component 1, HFC1)and subjective parameters(visual analog scale). After 7 days, for the second test period, the participants consumed an alternate food following the same protocol as during the first test period. Results Twenty-seven participants finished the protocol. The HFC1 values for the dominant eye in the monoglucosyl-rutin and placebo groups were 50.25±1.45 and 51.87±1.30, respectively. The subjective parameter of eyestrain was improved in the MGR group in comparison with those in the placebo group. Conclusion MGR supplementation has the effect to improve eyestrain symptoms due objectively and subjectively to VDT use. (UMIN Clinical Trials Registry ID: UMIN000034224)
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