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薬理と治療
Abstract
Objective To investigate the effects of citric acid and Moromi vinegar on improving fatigue and relieving psychological stress, we conducted a randomized, double-blind placebo-controlled, parallel-group study in healthy individuals aged≥20 years and <65 years who often experienced fatigue from their daily duties. The primary study endpoint was the Visual Analogue Scale(VAS)score for stress, and secondary endpoints included salivary chromogranin A, Profile of Mood States(POMS2), and Chalder Fatigue Scale score results. Methods One hundred participants experiencing fatigue were pretested, and 51 healthy individuals without diseases were selected. The 51 healthy individuals were then assigned to either a placebo group, a citric acid(citric acid amount: 810 mg)group, or a Moromi vinegar beverage (citric acid amount: 780 mg)group, and subjected to a 2-week ingestion period, after, stress tolerance test with an Uchida-Kraepelin(U-K)test was administered. Near the time that the stress tolerance test was administered, the VAS score for stress, salivary chromogranin A, and POMS results were evaluated. Additionally, Chalderʼs Fatigue Scale score was evaluated prior to and two weeks after ingestion. The study was registered with the University Hospital Medical Information Network(UMIN)Clinical Trial Registry before implementation (000035299). Results Although all participants completed the study, five who ingested<80% of the test products were excluded. The VAS stress scores and salivary chromogranin A results in the citric acid and Moromi vinegar beverage groups were significantly different from those in the placebo beverage group 2 weeks after ingestion, and the citric acid and Moromi vinegar-con taining beverages showed a work stress-relieving effect. Moreover, for POMS, there were significant differences in Anger-Hostility between the citric acid and placebo beverage groups 2 weeks after ingestion. There were no significant differences in the Chalder Fatigue Scale scores. Conclusion Citric acid and Moromi vinegar-containing beverages were shown to reduce stress during mental work in healthy individuals who perceived themselves as susceptible to experiencing daily fatigue.
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