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機能性原料のリパーゼおよびαグルコシダーゼ阻害活性―作用機序からみた機能性表示食品の安全性について―
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JPY
Abstract
Objectives This study investigated the safety of foods by assessing lipase and α-glucosidase inhibition activities of Terminalia bellirica extract and 12 other functional ingredients. Methods Lipase and α-glucosidase inhibition activities of T. bellirica extract, oolong tea extract, chitosan, Gymnema sylvestre extract, guava leaves extract, black tea extract, salacia extract, onion skin extract, tea flower extract, du zhong leaves extract, pu︱erh tea extract, green tea extract, and apple extract were determined. Orlistat or acarbose was used as the positive control. Results Each ingredient displayed lower inhibition activity than orlistat or acarbose. Out of the 13 ingredients, T. bellirica extract displayed the highest lipase inhibition activity in 13 ingredients. Chitosan and salacia extract inhibited α-glucosidase to the same level as T. bellirica extract. Conclusions It is unlikely that these ingredients cause side effects due to the inhibitory activities. However, the copious use of chitosan and salacia extract with T. bellirica extract may be a concern.
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