薬理と治療

Abstract

Objectives　Basic-research studies have reported the anti-fatigue effects of peptides and proteins derived from fish meat. However, very few full-scale investigations using randomized control trials（RCT）have been carried out to elucidate these effects so far. In this context, we conducted an investigative research using RCT on the effects of fish meat-derived peptides on improvement in alleviation of fatigue. Methods　We prepared tablets containing fish meat-derived peptides or placebo to administer to subjects in a“fish meat-derived peptides group”and a“placebo group”, respectively. Results　The administration of fish meat -derived peptides caused no adverse events based on hematological values, and none of the patients required treatment at the study site. There were no significant differences observed in any hematological values. However, according to the differences in scores on the Visual Analogue Scale（VAS）for fatigue between, before and after administration of the study tablets, subjects in the fish meat-derived peptides group showed significantly larger decreases compared to those in the placebo group, thus implying a significant fatigue reduction in the fish meat-derived peptides group. The results of a heart rate variability（HRV）analysis using TAS9View showed no significant differences or trends in any of the values. Conclusion　This study demonstrated that the oral intake of fish meat-derived peptides safely alleviated fatigue in humans. However, no objective data showing fatigue reduction was obtained, thus warranting further detailed investigation. UMIN-CTR（UMIN000034278）