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薬理と治療
Abstract
Background Intake of tripotassium citrate, trisodium citrate, and citric acid (hereafter collectively referred to as citrate)are suggested to improve quality of sleep and moods. Objectives The purpose of this study was to examine the effects of citrate on quality of sleep and mood in healthy people(those who do not have the disease). Methods Citrate(3000 mg/day)was continuously ingested for 14 days in Japanese men and women aged 20-65 who were unsatisfied with sleep, and the St. Mary Hospital sleep questionnaire, heart rate, sleep time, and POMS2, etc. as an index of objective and subjective sleep quality were investigated by a randomized, double-blind, placebo-controlled, parallel-group comparative study. Results Compared with the control group, the citrate intake group showed a significant increase in the refreshing degree upon waking up, a significant increase in the total sleep time, a significant decrease in the awakening frequency, and a significant decrease in the pulse rate (comparison between groups). In addition, there was a significant decrease in the POMS2 fatigue-inertia(FI)score, a significant decrease in the tension-anxiety(TA)score, and a significant decrease in the total mood disturbance(TMD)score in women(comparison between groups). Conclusions Oral intake of 3000 mg of citrate╱day was shown to improve sleep quality in healthy adults and mood in healthy adult women.(UMIN000037893)
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