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薬理と治療
Abstract
Objectives To evaluate the therapeutic potentials of a salt resistance plant-derived lactic bacterium(SR-PDLB)against mild symptoms of anemia, we designed a randomized double-blind placebo-controlled methodology and discussed the clinical efficacy/safety of the SR-PDLB-containing functional food. Methods Forty female healthy participants ranging in age from 28 to 55(three subjects in their 20 s, seven subjects in their 30 s, twenty-one subjects in their 40 s, and nine subjects in their 50 s)took part in our clinical trial equipped with the above-mentioned methodology. We divided them into two groups(n=20):placebo-control group(mean age±SD:43.5±7.9) and test group(mean age±SD:43.6±6.9). As the test food, a round tablet(0.3 g)containing Tetragenococcus halophilus[a lactic acid bacterium KURAHANA, strain no. LTK-1](5.0×1011 cells, 0.125 g)and dextrin(0.117 g)was used for oral ingestion of the tablet to the test subjects, two drops a day(total:0.6 g test food)for 12 weeks. On the other hand, the control experiment was performed in the same manner(total:0.6 g placebo), except ingesting a colorized round tablet(0.3 g)containing approximately twice the amount of dextrin(0.239 g)and a caramel colorant(6.0 mg). As a proof-of-concept proposal, we investigated the effects of the test food on measurements of our primary╱secondary endpoints for anemia therapy. Results According to the overall result of the primary ╱ secondary endpoints, it was pretty obvious that the test︱food intake revealed outstanding increases in both Hb and Ht values, as contrasted to the placebo control. But as a point worthy of special mention, the subjectsʼ feelings to their skin conditions in the test group were significantly greater, depending on the questionnaire scores about their subjective symptoms for anemia. That is why we have great concern that the improvement of skin condition might be caused by consuming the test-food for a prospective effective blood flow, regardless of whether the anemia is iron-deficiency or pernicious. Conclusions All through this trial, we keenly realized again the importance of consuming the functional KURAHANA from miso in a symbiotic manner. Our experimental results support the fact that daily ingestion of SR-PDLB-containing functional foods can reveal a kind of anti-anemia action, taking advantage of significant increases in Hb concentration, Ht volume, and so on(. UMIN ID: UMIN000037688)
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