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薬理と治療
Abstract
Objectives The pulp(precipitated fraction)that is present in the juice of Satsuma mandarin (Citrus unshiu Marc.)contains a high concentration of β-cryptoxanthin(β-CRP). β-CRP has been reported to have various health effects in epidemiological surveys and intervention studies, and we have reported on the efficacy of β︱CRP at a dose of 1 mg/day or higher for improving lipid metabolism. Therefore, this time, we evaluated it at a lower dose and by RCT. Methods We conducted a randomized, double-blind, placebo-controlled, parallel-group comparison study. Subjects were healthy men and women between the ages of 20 and 64 with LDL cholesterol (LDL-C)in the borderline region and the mild symptoms region. The test diets were 0.5 mg/day of β-CRP, which were three soft capsules, and the intake period was 12 weeks. Blood and urine tests, physical examinations, and medical interviews were carried out before the intake, 6 weeks after the intake and 12 weeks after the intake. Results 37 people were subjects for analysis(β-CRP group: 19, placebo group: 18). In all cases, the LDL-C, the primary endpoint, had significantly decreased in the β-CRP group (129.9→123.2 mg╱dL, P=0.037)after 12 weeks of ingesting β-CRP. Except for smokers, comparing the β-CRP group and a subgroup, a placebo group with less dietary β-CRP(β-CRP group: 16, placebo group: 8), showed that the LDL-C in the β-CRP group significantly decreased compared with the placebo group after 12 weeks of ingestion(β-CRP group: 122.8, placebo group: 137.0 mg╱dL, P=0.019). Conclusions The β-CRP group showed reduced LDL-C compared to the placebo group. This result suggested that the intake of β-CRP at a dose of 0.5 mg╱day for 12 weeks improves lipid metabolism in people with higher LDL-C. (UMIN Trial ID: UMIN000036477)
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