薬理と治療

Abstract

Objective　This study aimed to investigate the effects of 4-week repeated oral intake of quercetin -containing supplement on the allergen-induced allergic reactions and subjective symptoms in Japanese adult males and females who complained of discomfort in eyes and nose Methods　A randomized, placebo-controlled, double-blind parallel-group study was conducted in 66 subjects（22-78 years old）with allergic symptoms of pollinosis. The subjects were daily given either the test product（200 mg quercetin）or the control product（vehicle）for 4 weeks. Before and after the start of the product intake, the scores of Japanese Rhino-conjunctivitis Quality of Life Questionnaire（JRQLQ）with other tests were examined in each subject. A new food-graded bioavailable formulation of quercetin, Quercetin phytosome® was used. Results　At 1 to 4 weeks after the start of the supplement intake, several scores of JRQLQ including allergic symptoms such as eye itching, sneezing, nasal discharge, and sleep disorder were significantly improved in the quercetin-containing supplement group compared to the placebo group. Further, based on original questionnaire and visual analogue scale（VAS）, the quality of life in these subjects was significantly improved. Little notable adverse effects were noted throughout the study. Conclusions　The results indicated that oral intake of quercetin-containing supplement might be effective for the reduction of some allergy symptoms derived from pollinosis.（UMIN-CTR000038765）.