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薬理と治療
Abstract
Background Several clinical trials have investigated the impact of olive-derived hydroxytyrosol(OHT)on the protection low density lipoprotein(LDL)from oxidative damages, but no systematic review was conducted. Objective The objective was to perform a systematic review with meta-analysis of randomized, placebo-controlled trials of OHT to evaluate its impact on decrease blood oxidized LDL (oxLDL)in the healthy adults or adults with mild diseases. Method A systematic literature search was conducted with scientific databases, register databases for clinical trials-systematic review, and common internet search-engines and done manually within scientific journals. The primary outcome measure was values of blood oxLDL. A random-effects model was used to calculate the standardized mean difference and 95% confidence interval(CI)as the difference between the mean for the treatment and placebo groups. Standard methods for assessing statistical heterogeneity and bias risk were used. The protocol for this study was registered to UMIN-CTR(No. UMIN000040080). Result Three studies met the inclusion criteria. The use of food containing OHT decreased level of blood oxLDL[standardized mean difference (SMD):-0.26;95% CI:-0.39, -0.12]. Heterogeneity was not observed in the meta-analysis. Bias risk for body of evidence was rated as medium. Conclusion This systematic review suggests that OHT decrease blood oxLDL in the healthy adults. However, it is required that further high-quality RCT trials are reported because publication bias cannot be ignored in this systematic review.
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