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Suppressive Effects of a Supplement Containing Pomegranate Fruit Extract on Urinary Stress in Women ―A Randomized, Single—blind, Placebo—controlled, Parallel—group, Three—arm Study:A Pilot Study―
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JPY
Abstract
Objective Lower urinary tract symptoms are caused by aging and decrease quality of life (QOL)even in healthy men and women. The objective of this pilot study was to investigate the effects of a supplement containing pomegranate extract(PE)on QOL compromised by problems in urination(frequent feelings of urinary urgency, etc.)among women who experience frequent daytime voiding. Methods A randomized, single-blind, placebo-controlled, parallel-group, three-arm study was conducted on 34 women between 20 and 69 years old, receiving 250 mg(Group H)or 125 mg(Group L)of PE or placebo(Group P)daily for 8 weeks. Efficacy on urinary stress was evaluated based on the OverActive Bladder questionnaire(OAB-q)and Kingʼs Health Questionnaire(KHQ). To assess voiding function and frequent feelings of urinary urgency, a urination diary was also used as an efficacy measure. Results H and L groups showed significant improvement in“Role limitations”in week 4 and “Incontinence impact”in week 8 in the KHQ. Group H also showed significant improvement in “frequent feelings of urinary urgency”in weeks 4 and 6. No serious adverse events associated with PE were seen in H or L groups. Conclusion The results of the pilot study showed that pomegranate intake may be effective in significantly improving the QOL associated with reductions in voiding frequency and feelings of urinary urgency. (UMIN-CTR:UMIN000033475)
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