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薬理と治療
Abstract
Background The suppressive effects of progesterone on uterine endometriosis, adenomyosis and leiomyomas have been known world-widely. As previously reported, progesterone inhibited DNA synthesizing activity enhanced by estradiol in immature rat endometrium, and danazol(an isoxazol derivative of the synthetic steroid 17α-ethinyltestosterone)lowered plasma gonadotropin levels with ovarian hypofunction, resulting in the decrement of DNA synthesizing activity in matured rat uterus. Methods We investigated the effects of medroxyprogesterone acetate (17α-acetoxy-6α-methylprogesterone), danazol and mifepristone(an anti-progestin as a progesterone-receptor-blocker)on uterine adenomyosis(UA)in SHN virgin mice, which were known to have a high potential of the spontaneous development of UA. Results Long-term administration of medroxyprogesterone acetate suppressed the development of UA with the ovarian hypofunction and the reduction of the circulating progesterone levels in mice. Danazol reduced the development of UA, resulted in the ovarian hypofunction with undetectable plasma levels of luteinizing hormone in mice. Mifepristone suppressed the development of UA with the shrinkage of the endometrial vascular system in mice. Conclusions Inhibition of progesterone or administration of anti-progestin demonstrated the suppressive effects on the development of UA in SHN virgin mice.
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