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薬理と治療
Abstract
Background Owing to the escalated use of smartphones, visual display terminal (VDT)exposure time has become extremely long. Temporary myopia-like changes occur due to the load on the eyes caused by VDT activity. It is expected that temporarily impaired visual function can improve by suppressing axial length elongation, suppressing choroidal thinning by crocetin, and improving blood flow by the use of Ginkgo biloba extract. Objective This clinical research evaluates whether a crocetin plus Ginkgo biloba extract supplement(CG)improves temporarily impaired visual function. Study design This was a randomized, placebo-controlled, double-blind crossover study. Healthy individuals between the ages of 20 and 40 years and engaged in VDT activity on a daily basis, were given the CG or a placebo for 4 weeks each, and their eye function examined. Results The equivalent spherical power was significantly higher values in the CG group compared in the placebo group at week︱4(P<0.05). No significant difference between the two groups was observed in axial length or in choroidal thickness, but stratified analyses showed significant suppression of axial length elongation and increase in choroidal thickness. Conclusion Ingestion of CG for 4 weeks increases the equivalent spherical power, suggesting that CG ingestion may improve temporarily impaired visual function. (UMIN000040010)
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