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Licorice Flavonoid Oil Concentrate Solution Reduced Visceral Fat and Total Abdominal Fat in Healthy Subjects in a Randomized, Double—blind, Placebo—controlled Trial
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JPY
Abstract
Objectives Ingestion of licorice flavonoid oil(LFO)has been shown to reduce abdominal fat and/or total body fat. We conducted a randomized, double-blind, placebo-controlled trial to confirm the effects of LFO on abdominal visceral╱total fat area, body fat mass, body weight, body mass index(BMI), waist╱hip circumference, and safety parameters in healthy Japanese subjects. Methods Participants of both sexes aged≥20 to<65 years with a BMI of≤23.0 to<30.0 were enrolled and assigned to two groups and administered either a daily dose of placebo or LFO concentrate solution containing 3% glabridin(LFO(3%))100 mg for 12 weeks. Body fat mass was determined by dual-energy X-ray absorptiometry and abdominal total╱subcutaneous ╱visceral fat area was measured by computed tomography at the predetermined time points. Hematologic╱biochemical analyses, urinalysis, and adverse events╱reactions were also evaluated. Results A total of 200 participants were enrolled(100 per group), of whom 160 were included in the efficacy analysis(placebo n=81, male 25; LFO(3%)n=79, male 24). LFO (3%)ingestion significantly reduced abdominal total╱visceral fat area from baseline, with a significant difference between the groups. Stratified analysis demonstrated that LFO(3%) tended to increase lean body mass in men but not in women. No clinically relevant adverse events related to LFO(3%)ingestion were observed. Conclusions LFO(3%)100 mg(3 mg glabridin)reduced abdominal total╱visceral fat in healthy volunteers. (UMIN000034521)
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