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薬理と治療
Abstract
Objectives The aim of the present study was to investigate effects of tablets containing soy-derived peptide(SOYLAX®)and collagen-derived peptide(GPX®)on responses to mental stresses in healthy human. Methods In this crossover trial, 10 healthy volunteers were recruited. In the 1st phase, test articles(containing 1000 mg of SOYLAX® and 1000 mg of GPX® per 3 tablets)were administered to half of subjects and placebo tablets were administered to the other half subjects. After one-week washout period, opposite order of tablets were administrated respectively in the 2nd phase. In each trial, Visual Analogue Scale(VAS), Profile of Mood State 2nd Edition-Adult Short(POMS)and State-Trait Anxiety Inventory (STAI), concentration of salivary cortisol, blood pressure, pulse rate, electroencephalogram and electrocardiogram were repeatedly evaluated after administrations. Kraepelinʼs arithmetic test was carried out between each evaluations as mental stress tasks. Results In the test articles group, lower POMS score of“Tension-Anxiety”, lower concentration of salivary cortisol, and decreased levels of fast frequency components on electroencephalogram were observed compared to those in the placebo group. Conclusions The tablet containing SOYLAX® and GPX® showed health benefits against task induced negative mood and would alleviate mental stresses without any side effects. (UMIN Study ID: UMIN000040411)
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