薬理と治療

Abstract

Objectives　The purpose of this study was to investigate the effects of dietary supplements containing salmon nasal cartilage proteoglycan（SPG）on the skin moisturization of healthy subjects worried about dry skin due to office air conditioning. Methods　A randomized, double-blind, placebo-controlled trial of 56 healthy subjects（aged 20-58 years）was studied. Subjects were randomly divided into two groups, a proteoglycan and a placebo group. The proteoglycan group ingested a supplement containing 5 mg of SPG a day for 6 weeks, and the placebo group took an equivalent amount of dextrin. In order to verify the change in skin condition due to SPG intake, the skin moisture content and transepidermal water loss（TEWL）of the cheek, neck, and leg parts were measured. Results　Regarding the cheeks of the subjects in their 40 s, there was a significant increase in skin moisture content after 6 weeks in the proteoglycan group compared to the placebo group. In female legs, there was significant TEWL suppression in the proteoglycan group after 3 weeks. In subjects aged 40 years and older with TEWL ≤22 g/h/m2, the proteoglycan group showed a significant increase in skin moisture content in the neck after 6 weeks and a significant TEWL suppression in the legs after 3 weeks. Conclusion　These results suggest that SPG intake has a moisturizing effect on the skin by improving skin hydration and TEWL. （UMIN-CTR ID；UMIN000042097）