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薬理と治療
Abstract
Background The effect of Alaska pollack protein(APP)intake on improving physical function has not been clarified. Objectives The aim of this study was to determine the effect of APP supplementation at breakfast for 12 weeks beyond habitual intakes on muscle mass and muscle strength in elderly people needing support. Methods Twenty-five elderly needing support males and females underwent 12 weeks of intervention. We applied the 4.5 g milk protein(MP)or 4.5 g APP as nutritional supplementation. Subjects were divided into two groups: APP intake(APP group, n=14), milk protein intake(MP group, n=11). The human trial of the present study is registered at www.umin. ac.jp/ctr/asUMIN000033941 Results There were no significant changes in skeletal muscle mass and skeletal muscle mass index before and after the intervention for both groups. However, in women who were judged to be able to walk alone, a significant increase in skeletal muscle mass(P<0.05)and skeletal muscle index(P<0.05)were observed after the intervention compared to before the intervention only in the APP group. Furthermore, as a result of calculating and comparing the amount of change in the skeletal muscle index before and after the intervention in both groups, APP group was found to be significantly higher than MP group(P<0.05) Conclusions These results suggested that APP supplementation at breakfast for 12 weeks was effective in increasing skeletal muscle mass in elderly women in need of support.
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