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マンゴスチンエキス含有食品の抗糖化作用―プラセボ対照ランダム化二重盲検並行群間試験―
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JPY
Abstract
Objectives This randomized, double-blinded, placebo-controlled, parallel-group study aimed to evaluate the antiglycation effects of Garcinia mangostana extract. Methods This study included 90 healthy participants who were randomly assigned to a test food group and a placebo group. Participants in the test food group consumed a test food containing G. mangostana extract(160μg/day as rhodanthenone B), while those in the placebo group consumed a placebo food. Pentosidine level(primary outcome)and glycoalbumin and glycated hemoglobin levels(key secondary outcomes)were evaluated after 8 weeks of intervention. Results Pentosidine and glycoalbumin levels were significant lower in the test food group than in the placebo food group(P<0.05). During the study period, no adverse events attributable to the test food were observed. Conclusions Overall, the study findings indicate that the foods containing G. mangostana extract have an antiglycation effect in healthy participants. (UMIN-CTR ID: UMIN000039948)
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