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薬理と治療
Abstract
Objective This study aimed to evaluate the effects of ingesting seaweeds containing acidic water-soluble polysaccharides on salt intake in healthy subjects. Methods An open-label, randomized, parallel comparison study was conducted on 90 healthy subjects. The subjects were divided into three groups, namely, mekabu intake group, mozuku intake group, and a control group with no intake of seaweeds. The mekabu intake group received 35 g of raw mekabu(sporophyll of Undaria pinnatifida; salt equivalent: 0.2 g, acidic water-soluble dietary fiber: 0.7 g), whereas the mozuku intake group received 40 g of raw mozuku(Cladosiphon okamuranus; salt equivalent: 0.2 g, acidic water-soluble dietary fiber:0.8 g). The seaweeds were consumed once a day in the morning, noon, or evening meal, and prior to meal onset for seven days. The effect of seaweed consumption on salt intake was evaluated by comparing the estimated daily salt intake before and after the experimental diet. Results No significant change was observed in the estimated daily salt intake before and after the experiment in all groups. However, a significant decrease(P<0.05)in the daily salt intake was observed for both experimental groups when subgroup analysis was performed on subjects whose estimated daily salt intake before the experiment was above median value(8.6 g). Conclusion Regular pre-meal intake of seaweeds containing acidic water-soluble polysaccharides is an effective means for preventing and controlling hypertension caused by excessive salt intake. (UMIN-ID: UMIN000040665)
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